Esophageal Cancer Carboplatin and Doxil

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Carboplatin has the trade name paraplatin. It is an anti cancer drug (cytotoxic) and chemotherapy drug. It is also classified as an alkylating agent. It is used for treating esophageal cancer and other types of cancer which includes lung, heart, head and neck, endometrial, bladder, breast, cervical and central nervous system.

Carboplatin is generally given by an infusion into a vein. It can also be given intra peritoneal directly into the peritoneal cavity which is in the abdomen. The amount of carboplatin which is received may depend on many factors such as height, weight or other general health problems.

Carboplatin has some side effects. These side effects are often predictable in terms of their onset and duration. They are almost always reversible and will go away after the treatment is complete. There are also for minimizing or prevent side effects. The side effects and their severity depend on how much dosage the carboplatin is given. When high dosage is given, it may produce severe side effects.

Some of the common side effects that occur in patients are nausea and vomiting occurring within 24 hours of treatment, taste changes, low blood count, hair loss, weakness and blood test abnormalities (abnormal magnesium level). The less common side effects for the patients receiving carboplatin are diarrhea, constipation, mouth sores, burning sensation in the injection site, peripheral neuropathy, nephrotoxicity (kidney problems), central neurotoxicity, ototoxicity (hearing loss), abnormal blood liver enzymes, abnormal blood electrolyte levels, cardio vascular events etc.

The cancerous tumors are characterized by cell division and the normal cells stop dividing when they come in contact with like cells. Chemotherapy will halt the cell division. It works by damaging the RNA or DNA and if they are unable to divide they will die. The alkylating agents are most active in the resting phase of the cell. Several types of alkylating agents include hydrazines, triazines and mustard gas derivatives.

The generic name of Doxil is Liposomal doxorubicin. Doxil belongs to a group of agents called anthracycline antitumor antibiotics. It produces anticancer effects by binding to DNA and inhibiting the production of proteins. It is administered into veins and the dose depends on factors such as the conditions being treated, size and health of the patient.
The common side effects of treatment with Doxil are low red blood and white blood cell levels, pain, redness or swelling of the palms, mouth sores. The less common side effects are nausea and vomiting, diarrhea, constipation, hair loss, rash, loss of appetite and generalized weakness.

A phase study was conducted which evaluated the efficacy and toxicity of combination of Carboplatin and paclitaxel in the patients with esophageal cancer. In that study nearly 35 patients were enrolled and they were treated with paclitaxel 200mg/m2 intravenously over 3h and Carboplatin at an AUC of 5mg/h/ml. out of 35 patients, 33 patients were assessable for toxicity and objective response. The median response duration was 2.8 months and the median survival time was 9 months. The combination of Carboplatin and paclitaxel is a moderately active and tolerable regimen in advanced esophageal cancer.

Natural Remedies:
There are certain natural remedies that offer a promising cure for esophageal cancer. Along with the natural remedies and a well-researched different diet pattern, a few simple adjustments to your lifestyle can make a huge difference to your efforts for prolonging the life for several years. You can increase your chances of surviving esophagus cancer now by trying these proven natural remedies discussed here



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